A New Determinant of Candida glabrata Virulence: The Acetate Exporter CgDtr1
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چکیده
منابع مشابه
A New Determinant of Candida glabrata Virulence: The Acetate Exporter CgDtr1
Persistence and virulence of Candida glabrata infections are multifactorial phenomena, whose understanding is crucial to design more suitable therapeutic strategies. In this study, the putative multidrug transporter CgDtr1, encoded by ORF CAGL0M06281g, is identified as a determinant of C. glabrata virulence in the infection model Galleria mellonella. CgDTR1 deletion is shown to decrease the abi...
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Lara West, Douglas W. Lowman, Héctor M. Mora-Montes **, Sarah Grubb, Craig Murdoch, Martin H. Thornhill, Neil A.R. Gow , David Williams, and Ken Haynes From the Department of Microbiology, Imperial College London, London, SW7 2AZ, United Kingdom, the Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, AppRidge International, LLC, J...
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In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the s...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2017
ISSN: 2235-2988
DOI: 10.3389/fcimb.2017.00473